Some evidence has shown that the prevalence of DPN among people with diabetes in the UK is estimated to be 50% ( Sugimoto 2000), while the World Health Organization estimate for the UK is 29% ( Wild 2001). Stage 3: late complications of clinical neuropathy Sensory loss is slight, but pain at night common Signs of reduced or absent sensation with absent reflexes No symptoms or numbness/deadness of feet reduced thermal sensitivity painless injury Painless with complete/partial sensory loss Minor sensory signs or even normal peripheral neurological examination May be associated with initiation of glycaemic therapy Positive symptomatology (increasing pain at night): burning, shooting, stabbing pains ± pins and needlesĪbsent sensation to several modalities and reduced or absent reflexes